How long does Tapentadol stay in your system?

Let us first get a brief introduction to Tapentadol before we know how long does Tapentadol stays in your system.

Tapentadol is a novel opioid pain medication that is used to treat moderate to severe chronic pain. This opioid analgesic belongs to the drug class of benzenoid, a central nervous system depressant. Generic Tapentadol is available in various brand names of Nucynta, Aspadol, Tapal, Etadol, etc. 

Tapentadol working mechanism

Tapentadol has a dual mechanism of action, making it one of the safest and most effective analgesics compared to other opioids [1]. The mechanism of action of Tapentadol is activating the opioid receptors of the brain and regulating the neurotransmitter norepinephrine. Thus relieving the pain by blocking the transmission of pain signals from the nerves to the brain [2].

Pharmacokinetics

Absorption- Tapentadol is readily absorbed in the body upon consuming the pill. It has an extensive first-pass metabolism, medicines metabolizing in a specific body part that reduces concentration on reaching the site of action.

Distribution- After consumption, Tapentadol is widely distributed throughout the system.

Elimination- Tapentadol is metabolized in the liver and eliminated through the kidney.

How Long Does Tapentadol Stay In Your System?- Urine, Hair, And Blood

The half-life of Nucynta (Tapentadol) is 3.93 hours. About 95 percent of the drug is eliminated within 24 hours after oral administration [5]. 

However, how long Nucynta stays in your system can differ from person to person. The medicine generally lasts for 22 hours in most individuals [4].

How long does Tapentadol stay in the In urine?

Tapentadol dosage (Aspadol 100 mg) consumption can last in the urine for 3-4 days. However, it can last long in patients suffering from renal diseases.

How long does Nucynta stay in the hair?

Tapentadol (Nucynta) lasts longer in the hair follicles. Test results can show the presence of the drug in hair for up to 90 days from the last administration of the opioid.

How long does Tapentadol stay in the blood?

The opioid analgesic can be detected in blood tests for up to a day [4].

Factors Influencing How Long Tapentadol Stays In Your System

Some of the factors that influence how long Tapentadol Stays in your system are listed below -

• Dosage- Higher Dosage of this drug can stay in the system longer than a lower dosage.

• Metabolic rate- Metabolism is influenced by lifestyle habits, genetic makeup, and body weight. People with higher metabolism rates metabolize the drug faster.

• Age- Younger people have fast metabolism compared to older people. Therefore, Tapentadol may leave the system more slowly in older people.

• Tolerance- Long-term use of Tapentadol can build tolerance. This indicates that the body gets used to the medication and thus does not show an effective result. 

Will Tapentadol (Nucynta) show up on a drug test?

Specific tests can detect the presence of the Tapentadol drug in the system. It shows up as an opiate on a drug screen [6]. However, the precision of these test results depends on the duration from the time of consuming the medicine to the time of tests done. 

The bottom line

When we talk about medicine, everybody wants to get a clear view of the medicine and clear the doubts they have about it. In this blog, we have tried to cover everything possible about how long Tapentadol stays in your system. It should be noted that the duration might vary depending on individual factors such as weight, age, pill strength, metabolism, etc. Moreover, Tapentadol can show up in drug tests. Hence if you are going for tests, it is advisable to stop taking the pills for a few days.