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Tapentadol is a centrally-acting opioid analgesic approved by FDA for treating severe acute and chronic pain. With a dual mode of action, Tapenatdol is one of the safest, most well-tolerated, and effective most opioid analgesics on the market.

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Legal Status

Australia (AU)- S8 (Prescription only)

Canada- Schedule I (Prescription only)

UK- Schedule II (Prescription)

USA- Schedule II (Prescription only)

FDA approval Yes, In 2008
Habit-Forming Yes
Therapeutic Class Pain analgesic
Action Class μ-opioid receptor & norepinephrine reuptake inhibitor (NRI)

What is Tapentadol?

Tapentadol is a prescription pain medicine for treating moderate to severe pain in adults. It is an opioid analgesic that works on the central nervous system (CNS). The efficacy of Tapentadol is recognized for treating acute and chronic pain conditions. It is an around-the-clock medicine when the first line of pain treatment is ineffective.

Tapentadol Brand Name

It is marketed under several trade names. These brands have the same active compound, tapentadol hydrochloride, and working process. The most common among them are:

How Does Tapentadol Work?

Tapentadol is an oral medication with a dual mode of action. It works as a chemical that activates the opioid receptors in the brain and restricts the reuptake of norepinephrine (a hormone that helps the transmission of nerve signals). The restriction of norepinephrine reuptake results in the analgesic effect of the medicine. Thus, Tapentadol imparts its therapeutic effect by altering the perception of pain in the CNS.

The bioavailability, or ability of Tapentadol to be absorbed by the body, is 32%. The medicine compounds' metabolism, or breaking down, occurs in the liver. The elimination half-life, or the time it takes for the medicine to be reduced by half, is 4 hours. Excretion occurs through the kidney in the form of feces and urine.


What Is Tapentadol Uses For?

Tapentadol's uses approved by the FDA are mentioned below:
  • This opioid medicine helps treat short-term and prolonged musculoskeletal pain, such as arthritis or other bone and muscle issues.
  • It is an effective treatment for diabetic neuropathic pain.
  • Studies show Tapentadol effectively treats phantom pain (a pain sensation experienced from amputated body parts).

Other non-medical uses of Tapentadol can also provide relief from postoperative pain symptoms. Studies indicate this opioid analgesic has proven to improve pain levels in fibromyalgia patients (wide-spreading muscle pain).

Benefits Of Tapentadol

  • Compared to other opioid analgesics, Tapentadol has higher tolerability (the degree to which the consumer can avoid side effects).
  • It has lower serotoninergic effects than other analgesics, which means it potentially has less effect on serotonin (a chemical that helps function the brain and nerves).
  • It is an affordable opioid treatment.
  • It provides better pain relief.
  • Tapentadol has a fast-acting mechanism that works within 30 minutes of consumption.
  • Tapentadol has comparatively less effect on the gastrointestinal tract than other opioids, affecting the intestines and stomach.


Tapentadol Dosage

Tapentadol is available in two dosage formulations:
  • Tapentadol Immediate Release (IR)
  • Tapentadol Extended Release (ER)
The IR formulation works faster compared to the ER, which lasts longer. This opioid pain medicine is available in several dosages. The standard Tapentadol dose is 100 mg, which should be taken with a 4 to 6 hours gap. The maximum dose of the pain medicine is 700 mg on the first day and 600 mg on the subsequent days. However, health experts might suggest the dose and duration based on the following conditions.
  • The Severity of the medical condition
  • Response to the opioid treatment

Note : Do not alter the dose or duration for longer than the prescribed period.

Tapentadol Overdose

Taking this medicine in more than the prescribed quantity can result in an overdose. Seek immediate medical help if you suffer from overdose symptoms such as passing out and breathing difficulties.

Do not take two tablets simultaneously to compensate for the missed dose upon missing dose. Take medicine as per the daily routine.

Tapentadol Withdrawal

Abruptly quitting the medication can cause withdrawal symptoms of anxiety, loss of appetite, etc. Healthcare professionals recommend the Tapentadol tapering-off method by lowering the medicine dosage slowly and then stopping it.

How To Use Tapentadol Pill?

  • Take one dose of medicine orally with plain water.
  • Do break or chew the pill.
  • One can take the opioid medicine with food or on an empty stomach.
  • Individuals taking the Tapentadol ER tablet should maintain a gap of 12 hours.
  • Take this medicine strictly as per the instructions given by your physician.

Factors That Affect The Efficacy Of Tapentadol

  • Dosage : The higher the pain medication's dosage strength, the better the medication's efficacy. However, changes in the dose strength should be made under the supervision of a health expert.
  • Metabolism : Individuals with a poor or slow metabolism rate.
  • Age and low physical activity : older adults and people with less physical activity will have a slow metabolism.
  • Tolerance : Individuals who have built a tolerance to the medication will require dose adjustments
  • Overall health : Consumers with underlying health conditions or higher body mass will enjoy fewer benefits.


Some Warnings of Tapentadol

  • Do not consume alcohol or any other addictive substances with Tapentadol.
  • Patients suffering from impaired Gastrointestinal motility, such as bowel inflammation, constipation, gastrointestinal obstructions, etc., should take prior consultation.
  • Patients suffering from infectious diarrhea associated with Salmonella, toxigenic E. coli, etc., may suffer from prolonged and worsening conditions.
  • Individuals suffering from prior addiction issues should take consultation with a doctor.
  • Avoid taking the medication if you are a patient with high blood pressure, respiratory depression, or intracranial pressure (brain injury).

Before taking

  • Patients with a medical history of seizures or liver and kidney disease should consult a doctor.
  • Inform your doctor if you have asthma, allergy, or pancreatic disease.
  • Do not drive or operate heavy machinery while taking Tapentadol.
  • Pregnant and nursing mothers should consult a healthcare professional before taking this pain medicine.
  • Tapentadol is not recommended in adults below 18 and above 65 years.
  • Tapentadol can be habit-forming and should not be taken for more than three weeks.

Drug interaction

Interactions of Tapentadol

The opioid analgesic interacts with 372 drugs (183 major, 188 moderate, and 1 minor interaction). Avoid taking the following medicines while taking Tapentadol.
Major Interaction Moderate Interaction
Amphetamine Apomorphine
Baclofen Bitolterol
Butorphanol Brexanolone
Chlormezanone Cetirizine
Diazepam Dicyclomine
Esketamine Entacapone
Halazepam Flibanserin
Methocarbamol Ketamine

Note : This is not a complete list of all the drugs. Consult a health expert for further assistance.

Side Effects

Side Effects of Tapentadol

Common Tapentadol side effects are mild and do not require immediate medical attention.
  • Nausea or Vomiting
  • Dizziness
  • Drowsiness
  • Constipation
Seek help from a doctor at once if you experience any of the following:
  • Severe dizziness, drowsiness, or confusion
  • Irregular breathing
  • Fainting
  • Anxiety or hallucination
  • Seizure
The side effects of Tapentadol mentioned above are not a complete list of all the possible symptoms.
Medically reviewed by:
Last reviewed: 7th March 2023

frequently asked questions

Needs Answer? Find them here

How long does Tapentadol stay in your system?
The efficacy of Tapentadol lasts for about 4 to 6 hours. However, age, underlying health conditions, or metabolism can alter the duration.
Does Tapentadol show up on a drug test?
Specific tests can detect the presence of opioid medicine. It is detectable in urine for 3 to 4 days and in blood for a day. Tapentadol lasts for up to 90 days in hair.
Is Tapentadol a controlled substance?
Yes, the Tapentadol Schedule is II according to the classification given by the Drug Enforcement Administration.
How much Tapentadol can I take?
Tapentadol IR can be taken every 4 to 6 hours, while Tapentadol ER can be taken after every 12 hours. However, it is necessary to consult your doctor before taking opioid medicine.
Is Tapentadol IR better than ER?
Both the Tapentadol formulations have the same efficacy and working process. However, the onset of action of ER is slow but lasts longer, and the IR has a quick action but lasts comparatively less.
Where can I buy Tapentadol online at a reasonable price in the USA?
One can buy Tapentadol at the best price from Remedy Counter. This online pharmacy ensures genuine and fast delivery of medicines without any prescription.
Can you drink alcohol with Tapentadol?
Do not drink alcohol while on Tapentadol, as the interaction can cause severe risks of drowsiness, dizziness, respiratory depression, etc.

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