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Sildenafil is a class of drug called phosphodiesterase 5(PDE5) inhibitors that helps in treating erectile dysfunction. Available in various brand names, the Sildenafil Citrate enables you to get an erection within 30 minutes of intake.

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Legal Status

Australia (AU)- S4 (Prescription only)

Canada- Prescription only

UK- Prescription and Over the counter (OTC)

USA- Prescription only

FDA approval Yes, In 1998
Habit-Forming No
Action Class Phosphodiesterase-V inhibitors

What is Sildenafil?

Sildenafil is an oral medicine approved by the FDA for treating erectile dysfunction and pulmonary arterial hypertension (PAH). Erectile dysfunction is the inability to get and maintain an erection for a long period, whereas PAH is a type of high blood pressure that affects the blood vessels of the lungs and heart.

Sildenafil is a class of drugs called phosphodiesterase (PDE5 inhibitors) that cause blood vessels to relax and widen to improve blood circulation.

Brand Name

The generic Sildenafil is available under numerous brand names. Generic versions are named and produced after their active ingredient, whereas brand name refers to the name given by the manufacturing company.

The Sildenafil brand includes-

How Does Sildenafil Work?

The blue ED pill works by blocking the PDE5 enzyme that breaks down chemicals called nitric oxide needed for an erection. The increase in the NO level in the body helps widen the blood vessel, allowing better blood flow in the abdominal region, thus causing an erection. The medicine gets metabolized in the liver and is eliminated by the kidney. The average time needed to break down the compound to half is called the half-life of a drug and is about 3 to 4 hours.


What Is Sildenafil Used For?

Sildenafil citrate, also known as the “Blue Pill,” helps treat erectile dysfunction from numerous physiological factors, including obesity, high blood pressure, and Multiple sclerosis. It is approved to treat PAH in many countries, including the United States and the United Kingdom.

The blue pill for ED can enhance the heart’s ability to deliver oxygen to the muscle.

Benefits Of Blue Pills For Men

Studies conducted before and after the approval of Sildenafil at a higher dose than the recommended 100mg showed no significant health risk.

Off-label benefits of using the blue pill for ED include athletes, jet-lagged travelers, and mountaineers. The use of Sildenafil also helps with improving the symptoms of urinary issues such as incomplete bladder emptying, urinating for a long period, and nocturia (waking up at night to urinate).


Sildenafil Dosage

The Sildenafil brands are available in numerous strengths and dosages prescribed by doctors depending on the condition. Factors such as the patient's medical history, age, and severity determine the dose and strength of the pill.

The standard dose of the blue ED pill is 100mg. However, it is also available in 25mg, 50mg, 150mg, and 200mg.

Beginners are advised to start with a lower dose of Sildenafil 25mg, which can be gradually increased depending on the person's need.

How To Use Blue Ed Pills?

Sildenafil citrate is available as oral tablets that should be taken by mouth without being broken or crushed. The use of the medicine is not advisable for men below 18 years. The intake of the blue pill with food rich in fat can slow the drug's metabolism. It can also increase the risk of diarrhea.

The pill should be taken 30 minutes to 1 hour before intercourse. It should not be taken more than once daily. The long-term use of the medicine is safe, with a very low risk of addiction and dependency.

Factors That Affect The Efficacy Of Sildenafil Citrate

The effects of pills begin within 20 to 30 minutes. Certain factors can, however, slow the mechanism of the blue pills for men, thus taking longer to act.

check Age of the person - 

Since the rate of metabolism decreases with age, older men take longer to break down and eliminate the compound from the body. Thus, the blue ED pill's action lasts longer in older men, typically over 65 years.

check Dosage-

The strength of your pill affects the drug's potency. A high dose (Sildenafil 200 mg) may have a longer-lasting effect than smaller doses. However, higher strengths of the medicine should be taken after consulting a doctor.

check Metabolism-

People with a slower metabolism take longer to break down the compound, meaning it will take longer to start acting.

check Lifestyle-

Poor lifestyle choices such as smoking can lower blood flow, making the ED pill less effective.

check Psychological state-

Mental health issues such as stress, nervousness, anxiety, and depression can affect sexual activity. The ED pill will not work unless you are sexually aroused.

check Overall Health-

Medical conditions such as multiple sclerosis (MS) and diabetes can affect the potency of Sildenafil tablets.


Some Warning of Sildenafil

  • The blue pill should not be taken with grapefruit, pomegranate, and pomelo juices, as they lower the effectiveness of the medicine.
  • Consumption of alcoholic beverages with the ED pill can reduce its benefits and cause headaches and flushing.
  • Intake of milk with Sildenafil citrate can slow its metabolism as they are high in fat percent.

When To Visit A Doctor?

Suffering from occasional erectile dysfunction is common and requires no medical attention. However, it is essential to consult a physician in the following cases.
  • If there are signs of other conditions apart from ED.
  • In cases of premature or delayed erection.
  • When the condition is frequent.
  • If you have other underlying medical conditions, such as coronary artery disease.

Before taking

  • Check the ingredient list with your pharmacist to rule out any possible allergies.
  • Before taking the ED pill, inform your doctor of any heart disease, such as previous heart attacks and irregular heartbeat.
  • Medical conditions such as sickle cell anemia causing blood cells, Peyronie's disease resulting in painful erection, and eye disorders such as retinitis pigmentosa should take Sildenafil dosage after consulting a doctor.
  • Taking the blue ED pill with stomach ulcers may cause bleeding.
  • Before surgery, inform your doctor about taking Sildenafil tablets.

Facts & Myths On Sildenafil Citrate

  • The use of Sildenafil tablets does not protect from sexually transmitted diseases like AIDS.
  • It doesn't change the shape and size of your penis.
  • For many men, the Sildenafil tablet may not work the first time. It is advised that such patients take medicine at least eight times before changing the dose or the drug.
  • It is not a mood stimulant, meaning the ED pill will not work until you are aroused.
  • Sildenafil citrate does not give instant erection and takes 20 to 30 minutes to work.
  • The medicine doesn't increase your sexual urge.
  • Feelings of anxiety, depression, or nervousness often cause Viagra not to last as long or be as effective.
  • Sildenafil or its brands are not meant for women until your physician has prescribed it for PAH.

Drug interaction

A " Drug interaction " is a change in how a drug acts in the body when taken with other medicines and compounds.

Sildenafil can interact with 315 medicine, and this is not the complete list of all the possible interactions. Do not interpret this information without the guidance of a physician. Take medical advice immediately if you believe you are experiencing any drug interaction side effects.

Drug Interaction
Abametapir, Emapalumab, Meprednisone, Abrocitinib, Givosiran, and Daclatasvir. Increases the concentration of Sildenafil in the blood.
Clindamycin Metabolism of Clindamycin decreases.
Ziprasidone, Aldesleukin, Doxepin, Flupentixol, Isosorbide, Bromocriptine. Increases the risk of hypotension (drop in blood pressure) and fainting.
Spirapril It may increase the antihypertensive activities of Spirapril.
Betamethasone, Montelukast, Raltegravir, Tacrine, Carbimazole. The risk of rhabdomyolysis (breakdown of muscle tissue), myopathy (muscle weakness), and myoglobinuria (excess amount of protein in the urine) increase.
Capecitabine Metabolism of Capecitabine decreases.
Lepirudin, Dalteparin It increases the risk of hemorrhage
Darunavir, Ledipasvir, Furosemide, Entacapone, Grazoprevir, Ofloxacin. The risk of side effects increases.

Side Effects

Side Effects of Sildenafil

Dizziness, Trouble breathing, Allergic reaction, Headache, Flushing, Nasal congestion, Blurred vision, Prolonged erection, and lightheadedness are common side effects that one may suffer from. Vision changes may also occur, including blurry eyesight, difficulty telling green and blue colors apart, and sensitivity to light.

Get up slowly from a lying or sitting position to lower the risk of drowsiness and dizziness. Rare side effects may include:
  • A sudden decrease in hearing.
  • Ringing in the ear.
  • Trouble breathing
  • Rashes
  • Swelling of the face and throat.
If any of these side effects get worse, inform your doctor immediately. Most side effects are mild and dose-related. Remember that this medicine has been prescribed because your physician believes its benefits outweigh its health risks.
Medically reviewed by:
Last reviewed: 7th March 2023

frequently asked questions

Needs Answer? Find them here

What does Sildenafil do for a man?
The use of Sildenafil helps men with erectile dysfunction. It expands the blood vessels in the abdomen, allowing blood flow to the penis for a firm erection.
What happens when you take Sildenafil?
The intake of Sildenafil citrate helps in treating erectile dysfunction by improving the blood flow into the penis by relaxing the blood vessel.
How long does Sildenafil take to kick in?
It takes 20 to 30 minutes for Sildenafil to start working.
Is Sildenafil as effective as Viagra?

Viagra is formulated with Sildenafil as its active ingredient, thus showing similar action and benefits.

Does Sildenafil keep you hard after coming?
No, it doesn't keep you hard after coming.
Can I take Sildenafil every other day?
Yes, Sildenafil is safe for long-term use and can be taken daily.
Why is Sildenafil not working anymore?

Sildenafil can lose effectiveness over time due to changes in the body and the person's health. It can also indicate a significant obstruction to the blood flow in the abdominal region.

Is it safe to mix Sildenafil and Tadalafil?
Mixing Sildenafil and Tadalafil is not advisable as they may cause major drug interaction resulting in palpitation, dizziness, headache, flushing, lightheadedness, and painful erection.

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