What Is Nootropil Used For?

So, what is Nootropil used for?

Let us dive into the benefits and medical uses of Nootropil and how it can be an effective treatment option for you. 

Nootropil 800mg is a Piracetam brand that belongs to the drug class Nootropics [1]. The use of Nootropil as a cognitive enhancer has been used in Europe for decades now. But its beneficial profile has more to it than just enhancing your brain activity. 

This guide looks into an overview of Piracetam and the advantages of taking the Nootropic. 

What Is Nootropil 800 mg?

Piracetam, the active compound of Nootropil 800mg, belongs to the pyrrolidone family of chemicals and first came to prominence as a Nootropic in the year 1970 [2]. 

A Nootropic agent refers to compounds that can enhance people's memory and learning ability. 

The pyrrolidone compounds are unique in their chemical structures and thus can affect the central nervous system differently than the other Nootropics [2]. 

Nootropil 800 mg is available in the USA as a nutritional supplement and is approved for treating myoclonus in Europe [3]. Physicians also prescribe patients to buy Nootropil 800mg for dyslexia and seizure. So, let us better understand the benefits and uses of Nootropil 800 tablets.

Top 7 Nootropil Uses

Here are some prevalent Nootropil 800 benefits based on research and consistent with user experiences and anecdotes. 

Treats Epilepsy-

Epilepsy or myoclonic seizures is a neurological disorder affecting the central nervous system resulting in abnormal brain activity, causing shock-like jerks of a muscle or a group of muscles [4, 5]. 

Philip N. Patsalos, from UCL Institute for Neurology, described Piracetam as effective in treating myoclonic seizures [6].  

“Piracetam is particularly effective for myoclonic seizure treatment. Its effects are immediate, profound, and long-term with no development of tolerance.”

Another clinical study evaluating the use of Piracetam in treating cortical myoclonus suggests that using Piracetam as a monotherapy or adding it with an existing epileptic drug may cause a significant improvement in the patient [7]. 

The Nootropil 800 mg price is affordable, making it a popular seizure treatment choice. The long-term use of Piracetam (Nootropil 800) during 1.5 years of treatment effectively improved the condition with no signs of adverse effects [8]. 

For Anxiety-

Animal studies and anecdotal reviews indicate using Nootropil to lower anxiety and elevate the person's mood [9]. A study shows how Piracetam or Nootropil 800 can help manage anxiety [10]. 

"Piracetam, if taken at 100 mg per kg, causes a higher cortical concentration of 5-hydroxytryptamine. It is seen that a lower concentration of 5-hydroxy indole acetic acid causes a reduction of 5-HT turnover."

5-hydroxytryptamine or Serotonin positively impacts neural regulation, thus improving users' mood and anxiety [11].

As A Cognitive Enhancer- 

Piracetam or Nootropil 800mg is prescribed in many European countries for cognitive impairment and dementia [12]. Nootropil 800 is proven to help postoperative cognitive dysfunction by affecting neuronal metabolism. It improves glucose utilization within neurons and thus enhances the synthesis of nucleic acids and neuromodulators in the brain. It can be crucial in preventing postoperative cognitive dysfunction [13]. 

Another possible theory that suggests the ability of Piracetam to improve cognition is its ability to make the cell membrane more fluid. It assists in making it very effective in sending and receiving signals by cell [14,15].

In one study, Nootropil 800 or Piracetam was observed to improve brain activity by enhancing the blood supply and improving glucose and oxygen consumption [16,17]. The impact of Nootropyl (Piracetam) in improving verbal learning for a week showed significant improvement with no sign of an adverse effect [18]. 

A 21 days study of 16 volunteers with dyslexia and 14 healthy adults potentially improved verbal learning by 15% and 8.6%, respectively [19]. 

Reduce Dementia And Symptoms Of Alzheimer’s Disease-

Dementia is a condition that affects the memory, social, and thinking ability of a person [20]. Studies suggest that dementia and Alzheimer's may occur due to the build-up of amyloid-beta peptides as they clump together between nerve cells and affect the CNS's function [21,22]. Piracetam prevents Alzheimer's and dementia by preventing the accumulation and clumping of amyloid-beta peptides between the nerve cells [23,24]. 

A survey done on 1500 people with brain impairment and dementia indicates that about 61% of people taking Nootropil or Piracetam 800 mg helped improve mental performance [25]. 

For Pain Relief And Inflammation-

Inflammation is the natural response of your immune system that helps the body to fight against diseases. Animal studies show that Piracetam has antioxidants that help reduce inflammation by neutralizing free radicals [26]. 

Another study supporting the ability of Nootropil to reduce inflammation is by suppressing the production of cytokines (a molecule that triggers inflammation by stimulating the immune response) [27,28]. Further, the use of Nootropil was effective in reducing pain related to inflammation [29,30]. 

For Vertigo-

Vertigo is described as dizziness or lightheadedness. A study exhibiting the effectiveness of Piracetam in vertigo indicates it to be an effective Pharmacotherapy option [31]. 

In a comparative study, Piracetam was found to be more effective in decreasing the frequency of vertigo than placebo [32]. 

Improves The Signs Of ADHD-

ADHD, or Attention-deficit/hyperactivity disorder, is a neurodevelopmental disorder that results in trouble paying attention, being overly active, and controlling impulsive behaviors [33]. The cognitive-enhancing ability of the Nootropil 800 tablet helps reduce the symptoms of ADHD by

• Boosting concentration.

• Improving energy level. 

• Increasing synaptic plasticity.

Patients with ADHD should take Nootropil or Piracetam doses ranging between 3200 – 6400 mg to get the desired effects [34].

Investigational Benefits Of Nootropil 

Along with the clinically established benefits of Nootropil, there are a few off-label investigational uses of the Nootropic. 

Reduction In Sickle Cell Disease- 

Studies show that using Nootropil can block and reverse the sickling of erythrocytes (blood cells). However, more studies need to be performed [35]. 

For Aphasia Following A Stroke-

Clinical trials show that Nootropil 800mg improves language measures following a stroke [36]. 

For Fetal Distress In Labor-

Nootropil is believed to promote the metabolism of the brain cell under hypoxic conditions. A study of 96 pregnant women was seen to potentially reduce the need for cesarean section delivery in women taking Nootropil 800mg [37]. 

References-

1. Piracetam - An overview | ScienceDirect Topics

2. The Pharmacological Treatment of Aphasia, ScienceDirect. 

3. Pharmacotherapy for Aphasia, ScienceDirect. 

4. Epilepsy - Symptoms and causes - Mayo Clinic

5. Myoclonic Seizures | Epilepsy Foundation

6. The Epilepsy Prescriber's Guide to Antiepileptic Drugs, Cambridge. 

7. Piracetam in the treatment of cortical myoclonus, PubMed. 

8. Antimyoclonic efficacy of piracetam in idiopathic generalized epilepsy, PubMed. 

9. Guide To The Best Nootropics For Anxiety & Depression, Outlookindia. 

10. Evidence that piracetam has an anxiolytic action, PubMed. 

11. Elevated anxiety and antidepressant-like responses in serotonin 5-HT1A receptor mutant mice, pnas.org. 

12. Presence of Piracetam in Cognitive Enhancement Dietary Supplements, NCBI. 

13. Effect of piracetam on the cognitive performance of patients undergoing coronary bypass surgery: A meta-analysis, NCBI. 

14. Effects of piracetam on membrane fluidity in the aged mouse, rat, and human brain, PubMed. 

15. Piracetam reverses hippocampal membrane alterations in Alzheimer's disease, PubMed. 

16. Piracetam and piracetam-like drugs: from basic science to novel clinical applications to CNS disorders, PubMed.

17. Piracetam and TRH analogs antagonize inhibition by barbiturates, diazepam, melatonin, and galanin of human erythrocyte D-glucose transport, PubMed. 

18. Increase in the power of human memory in normal man through the use of drugs, PubMed. 

19. Piracetam as an aid to learning in dyslexia. Preliminary report, PubMed. 

20. Dementia - Symptoms and causes - Mayo Clinic

21. Alzheimer’s Disease and the β-Amyloid Peptide, NCBI.

22. Aging promotes amyloid-β peptide-induced mitochondrial dysfunctions in rat brain: a molecular link between aging and Alzheimer's disease, PubMed. 

23. Piracetam inhibits the lipid-destabilizing effect of the amyloid peptide Abeta C-terminal fragment, PubMed.

24. Study of the protective effects of nootropic agents against neuronal damage induced by amyloid-beta (fragment 25-35) in cultured hippocampal neurons, PubMed. 

25. Clinical efficacy of piracetam in cognitive impairment: a meta-analysis, PubMed. 

26. Piracetam improves mitochondrial dysfunction following oxidative stress, NCBI. 

27. Analgesic activity of piracetam: effect on cytokine production and oxidative stress, PubMed. 

28. Effect of piracetam in models of experimental inflammation, PubMed. 

29. Analgesic activity of piracetam: effect on cytokine production and oxidative stress, PubMed. 

30. Analgesic effect of piracetam on peripheral neuropathic pain induced by chronic constriction injury of the sciatic nerve in rats, PubMed. 

31. The effectiveness of piracetam in vertigo, PubMed. 

32. Oral Piracetam vs Betahistine in Outpatient Management of Peripheral Vertigo; a Randomized Clinical Trial, NCBI. 

33. What is ADHD? | CDC

34. 7 Best Cognitive Enhancers For ADHD, mentalhealthcenter. 

35. Piracetam for reducing the incidence of painful sickle cell disease crises, PubMed. 

36. Pharmacological treatment for aphasia following stroke, NCBI. 

37. Piracetam for fetal distress in labour, NCBI.