Sildenafil is a class of drug called phosphodiesterase 5(PDE5) inhibitors that helps in treating erectile dysfunction. Available in various brand names, the Sildenafil Citrate enables you to get an erection within 30 minutes of intake.
Overview
| Legal Status |
Australia (AU)- S4 (Prescription only) Canada- Prescription only UK- Prescription and Over the counter (OTC) USA- Prescription only |
| FDA approval | Yes, In 1998 |
| Habit-Forming | No |
| Therapeutic Class | SEX STIMULANTS REJUVENATORS |
| Action Class | Phosphodiesterase-V inhibitors |
Sildenafil is an oral medicine approved by the FDA for treating erectile dysfunction and pulmonary arterial hypertension (PAH). Erectile dysfunction is the inability to get and maintain an erection for a long period, whereas PAH is a type of high blood pressure that affects the blood vessels of the lungs and heart.
Sildenafil is a class of drugs called phosphodiesterase (PDE5 inhibitors) that cause blood vessels to relax and widen to improve blood circulation.
The generic Sildenafil is available under numerous brand names. Generic versions are named and produced after their active ingredient, whereas brand name refers to the name given by the manufacturing company.
The blue ED pill works by blocking the PDE5 enzyme that breaks down chemicals called nitric oxide needed for an erection. The increase in the NO level in the body helps widen the blood vessel, allowing better blood flow in the abdominal region, thus causing an erection. The medicine gets metabolized in the liver and is eliminated by the kidney. The average time needed to break down the compound to half is called the half-life of a drug and is about 3 to 4 hours.
Used
Sildenafil citrate, also known as the “Blue Pill,” helps treat erectile dysfunction from numerous physiological factors, including obesity, high blood pressure, and Multiple sclerosis. It is approved to treat PAH in many countries, including the United States and the United Kingdom.
The blue pill for ED can enhance the heart’s ability to deliver oxygen to the muscle.
Studies conducted before and after the approval of Sildenafil at a higher dose than the recommended 100mg showed no significant health risk.
Off-label benefits of using the blue pill for ED include athletes, jet-lagged travelers, and mountaineers. The use of Sildenafil also helps with improving the symptoms of urinary issues such as incomplete bladder emptying, urinating for a long period, and nocturia (waking up at night to urinate).
Dosage
The Sildenafil brands are available in numerous strengths and dosages prescribed by doctors depending on the condition. Factors such as the patient's medical history, age, and severity determine the dose and strength of the pill.
The standard dose of the blue ED pill is 100mg. However, it is also available in 25mg, 50mg, 150mg, and 200mg.
Beginners are advised to start with a lower dose of Sildenafil 25mg, which can be gradually increased depending on the person's need.
Sildenafil citrate is available as oral tablets that should be taken by mouth without being broken or crushed. The use of the medicine is not advisable for men below 18 years. The intake of the blue pill with food rich in fat can slow the drug's metabolism. It can also increase the risk of diarrhea.
The pill should be taken 30 minutes to 1 hour before intercourse. It should not be taken more than once daily. The long-term use of the medicine is safe, with a very low risk of addiction and dependency.
The effects of pills begin within 20 to 30 minutes. Certain factors can, however, slow the mechanism of the blue pills for men, thus taking longer to act.
Age of the person - Since the rate of metabolism decreases with age, older men take longer to break down and eliminate the compound from the body. Thus, the blue ED pill's action lasts longer in older men, typically over 65 years.
Dosage-The strength of your pill affects the drug's potency. A high dose (Sildenafil 200 mg) may have a longer-lasting effect than smaller doses. However, higher strengths of the medicine should be taken after consulting a doctor.
Metabolism-People with a slower metabolism take longer to break down the compound, meaning it will take longer to start acting.
Lifestyle-Poor lifestyle choices such as smoking can lower blood flow, making the ED pill less effective.
Psychological state-Mental health issues such as stress, nervousness, anxiety, and depression can affect sexual activity. The ED pill will not work unless you are sexually aroused.
Overall Health-Medical conditions such as multiple sclerosis (MS) and diabetes can affect the potency of Sildenafil tablets.
Warning
Drug interaction
Sildenafil can interact with 315 medicine, and this is not the complete list of all the possible interactions. Do not interpret this information without the guidance of a physician. Take medical advice immediately if you believe you are experiencing any drug interaction side effects.
| Drug | Interaction |
|---|---|
| Abametapir, Emapalumab, Meprednisone, Abrocitinib, Givosiran, and Daclatasvir. | Increases the concentration of Sildenafil in the blood. |
| Clindamycin | Metabolism of Clindamycin decreases. |
| Ziprasidone, Aldesleukin, Doxepin, Flupentixol, Isosorbide, Bromocriptine. | Increases the risk of hypotension (drop in blood pressure) and fainting. |
| Spirapril | It may increase the antihypertensive activities of Spirapril. |
| Betamethasone, Montelukast, Raltegravir, Tacrine, Carbimazole. | The risk of rhabdomyolysis (breakdown of muscle tissue), myopathy (muscle weakness), and myoglobinuria (excess amount of protein in the urine) increase. |
| Capecitabine | Metabolism of Capecitabine decreases. |
| Lepirudin, Dalteparin | It increases the risk of hemorrhage |
| Darunavir, Ledipasvir, Furosemide, Entacapone, Grazoprevir, Ofloxacin. | The risk of side effects increases. |
Side Effects
Dizziness, Trouble breathing, Allergic reaction, Headache, Flushing, Nasal congestion, Blurred vision, Prolonged erection, and lightheadedness are common side effects that one may suffer from. Vision changes may also occur, including blurry eyesight, difficulty telling green and blue colors apart, and sensitivity to light.
Needs Answer? Find them here
Viagra is formulated with Sildenafil as its active ingredient, thus showing similar action and benefits.
Sildenafil can lose effectiveness over time due to changes in the body and the person's health. It can also indicate a significant obstruction to the blood flow in the abdominal region.
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