Tadalafil: Uses, Side Effects, Dosage, and Interactions

Overview
Uses
Dosage
Warning
Drug Interactions
Side Effects

Overview

Legal Status	Australia (AU)- S4 (Prescription only) Canada- Prescription only UK- Prescription USA- Prescription only
FDA approval	Yes, In 2003
Habit-Forming	No
Therapeutic Class	Sex stimulants rejuvenators
Action Class	Phosphodiesterase-V inhibitors

What is Tadalafil?

Tadalafil is a phosphodiesterase type 5 inhibitor (PDE5 inhibitor) medication and an effective Erectile Dysfunction treatment.

Erectile Dysfunction (ED) is an erection disorder in men that causes difficulty in attaining and maintaining an erection.

Along with erectile dysfunction (ED), it treats the symptoms of Benign Prostatic Hyperplasia (BPH), a condition that affects urination. This medication also aids in treating Pulmonary Arterial Hypertension (PAH), a high blood pressure condition affecting the lungs and heart.

Brand Name of Tadalafil

Tadalafil is sold under various brands or trade names.

The manufacturer assigns the brand name, whereas the generic name refers to the active ingredient.

The following are the various brand names of Tadalafil, all of which have the same active ingredients and modes of action:

How Does Tadalafil Work?

Nitric Oxide (NO), released from the nerve terminals and cells, stimulates the combination of cyclic guanosine monophosphate (cGMP). The cGMP is a secondary messenger that enhances the physiological process. It helps muscle relaxation of the corpus cavernosum (spongy tissue surrounding the penis) and widening of blood vessels to the penile region resulting in an erection.

However, the phosphodiesterase type 5 ( PDE5) enzyme breaks down the cGMP accumulation causing erectile issues.

Intaking of Tadalafil helps to stop the breaking of cGMP by inhibiting the PDE5 enzyme. This ED medication further enhances muscle relaxation and blood flow to the penis. The metabolism or breaking down of Tadalafil occurs in the liver. The average elimination rate or half-life of Tadalafil is 17.5 hours. Elimination of the drug occurs in the kidney through feces and urine.

Uses

What Are Generic Tadalafil Uses For?

It has the following medical uses:

Erectile Dysfunction

Tadalafil helps sexually stimulated ED patients achieve a firm erection by relaxing the muscles and enhancing blood flow in the penile region.

Benign Prostatic Hyperplasia (BPH)

Tadalafil relaxes the bladder and prostate muscles and helps with urinating difficulties.

Pulmonary Arterial Hypertension (PAH)

Tadalafil relaxes the blood vessels in the chest and treats the symptoms of PAH.

It has several off-label uses in addition to the prescription uses provided above:

This pill treats ED resulting from diabetes.
Many studies back the benefits of Tadalafil for muscle growth and pain relief.
Tadalafil improves joint pain or arthritis.
It is a promising treatment for chronic diseases associated with memory.

Benefits Of Tadalafil

Tadalafil is the most popular ED treatment due to the following advantages:

In comparison to other ED pills, the medicine's efficacy lasts longer.
This ED pill starts working faster within 30 minutes after consumption.
It is preferred by men over other ED medications because its action is unaffected by food consumption.
Tadalafil has a low risk of habit formation.
It helps increase testosterone levels, a male reproductive hormone.
The long-term use of it is safe. The medicine can be taken daily for 18 to 24 months without side effects.
Tadalafil can help treat high blood pressure.

Dosage

Tadalafil Dosage

Consult a medical professional before taking the ED medication. The dosage and duration of treatment depend on the severity, cause, age, and underlying medical conditions.

It is available in various strengths. It is important to note that you should seek the advice of a specialist before changing your medication dosage.

For Erectile Dysfunction:

The recommended starting dose for beginners is 2.5 mg.
Occasional users can take Tadalafil 20 to 30 minutes before sexual activity.
Regular users can take a single dose of the pill at a specific time every day to obtain the desired effect.

For Benign Prostatic Hyperplasia (BPH):

The recommended dosage for treating BPH is 5 mg daily. Take the ED medication at the same time each day for maximum efficacy and consistency.

If you are taking Tadalafil for erectile dysfunction (ED) and benign prostatic hyperplasia (BPH), you should take one daily dose of 5 mg or the dosage prescribed by your doctor.

For Pulmonary Arterial Hypertension (PAH):

Individuals with PAH may take 40 mg of Tadalafil daily.

How To Use Tadalafil?

Take the ED pill orally with plain water.
Do not chew or break down the pill.
Do not overdose on the pill. Take one tablet daily for ED or as the physician directs for PAH and BPH.
One can take the tablet with food or on an empty stomach.
Daily Tadalafil users should take the pill in the same routine to maintain regularity and enjoy the maximum benefit.

Factors That Affect The Efficacy Of Tadalafil

Certain factors impact the working of ED medicine.

Dosage: The inadequacy of the Tadalafil dosage might affect its working. In such cases, consult your doctor to adjust the prescription quantity.
Metabolism: Patients with poor metabolism can take longer to enjoy the medicine's benefits. Moreover, taking the pill way longer or just before sexual activity can also affect the efficacy of Tadalafil.
Age of the person: As the metabolism rate decreases with age, the effectiveness of the ED medication will take longer in older adults.
Lifestyle: People with low physical activity, abnormal sleep routine, or are overweight can be unresponsive or enjoy partial benefits of the treatment.
Psychological conditions: It is important to note here that it is effective in treating physical ED issues. If a person suffers from ED due to psychological problems such as anxiety, depression, or stress, they will not experience any benefits.
Overall health: Individuals with poor health conditions may have a low or slow effectiveness.

Warning

Some Warnings of Tadalafil

Taking Tadalafil with alcohol should be avoided. It and alcohol interaction can lower blood pressure and increase the risks of side effects such as fainting, headache, etc.
Avoid food such as grapefruit juice or other fruits rich in vitamin C. Tadalafil and grapefruit interaction can cause an increase in blood levels and the effects of the medicine.
Tadalafil consumption should be avoided if you are suffering from certain diseases.
- Cardiovascular disease : Cardiovascular disease: Patients with cardiovascular disease or heart conditions should avoid taking ED medicine as it increases the risks of cardiac arrest.
- Cerebrovascular disease : It is a condition associated with the blocking of blood supply to the brain. Patients with such diseases can suffer from a brain hemorrhage or stroke.
- Tadalafil effects on the kidney or Renal dysfunction : Individuals with this disorder should avoid or consult their physician for dose adjustments. It can cause difficulties in elimination and result in drug accumulation in the body.
- Retinitis pigmentosa : It is a genetic eye disorder that causes vision impairment. The intake of the ED pill can worsen the condition.

When To Visit A Doctor?

Under the following conditions, it is advised to consult a physician.

Visit a doctor if your ED is caused due to an underlying health condition such as diabetes, high blood pressure, or hardening of the arteries.
It is advisable to consult a doctor if you are undergoing medical treatment such as radiation therapy or prostate surgery.
If you are suffering from depression and stress, your doctor can help you find a better solution to manage ED.
Consult a doctor if your erection issue is frequent.

Before taking

Individuals below 18 years should avoid taking ED medicine.
Consumption of Tadalafil is not recommended in women.
Caution should be maintained by patients with seizures.
One should ensure that they are not allergic to any of the ingredients of the medicine.
Patients with medical conditions of liver disease, diabetes, hearing issues, etc., should consult a health specialist before taking the pill.
Let your doctor know if you are on any other medications before taking ED treatment.
Take this medicine as directed by your physician. Overdosing can cause Priapism, a condition that causes painful and prolonged erection.

Facts & Myths On Tadalafil

It does not protect consumers from sexually transmitted diseases like HIV/AIDS.
For this ED medicine to work, prior sexual stimulation is necessary.
ED medicine does not have anything to do with mood enhancement.
Tadalafil does not enlarge the size of the penis.
The medicine does not enhance sperm count.
It provides only a temporary solution for ED.

Drug interaction

Tadalafil Drug interactions

This PDE5 inhibitor might react with 285 drugs. These reactions can change the working of the medicine and increase the possibility of side effects.

Avoid the administration of the following medicines with Tadalafil.

Other PDE5 inhibitors.
Medications to treat BPH, such as Flomax.
Cardiovascular disease medicines such as Metoprolol Succinate ER or Metoprolol Tartrate
Do not take nitrates such as nitroglycerin, as the interaction can cause a sudden drop in blood pressure or other side effects.
PAH medicines such as riociguat
Antifungals such as ketoconazole
Antibiotics such as erythromycin
HIV/AIDS medicines such as ritonavir
Hepatitis C medicines such as boceprevir

Side Effects

Tadalafil Side Effects

Tadalafil is well tolerated, which indicates that it is safe and can be taken to a certain extent without causing adverse effects. However, improper medication use may result in risks and side effects.

Common symptoms

These side effects are mild and do not require immediate medical attention.

Upset stomach
Dry mouth
Sleepiness
Watery eyes
Flushing
Runny or stuffy nose

Severe side effects

Consult a medical professional if you experience any of the conditions listed below.

Chest pain
Chills or cold sweats
Fainting
Dizziness
Unusual or irregular heartbeat

It is not a complete list of all the side effects of Tadalafil that one can experience.

Medically reviewed by:

Dr. Uche Ogbuagu (Medical Researcher)

Last reviewed: 7th March 2023

frequently asked questions

Needs Answer? Find them here

Does Tadalafil expire?

Yes, like any other medicine, Tadalafil will expire. The shelf life of Tadalafil is two years from the date of manufacture.

Can women take Tadalafil?

The ED medicine is not recommended for women. However, for Pulmonary Arterial Hypertension, prior consultation from a medical expert is mandatory.

How long does Tadalafil stay in your system?

The half-life of Tadalafil is 17.5 hours, and therefore it lasts in the system for up to 36 hours.

How long does Tadalafil take to work?

The oral Tadafil tablet takes about 20 to 30 minutes after consumption to start working.

Does Tadalafil increase testosterone?

Yes, the consumption of the ED pill can help to increase the testosterone level.

Can Tadalafil lower blood pressure?

Yes, studies on high blood pressure patients shows that Tadalafil reduced the mean ambulatory blood pressure. This indicates that the ED medication can be an effective treatment for lowering blood pressure.

Does Tadalafil increase size?

Tadalafil is an ED medication that helps to get and sustain an erection. This oral treatment does not improve the size of the penis.

Can the use of Tadalafil affect fertility?

Tadalafil is a male enhancement pill. There are no studies to prove the concern of fertility. It is best to take suggestions from a medical practitioner for further assistance.

Where can I purchase Tadalafil without a prescription?

One can buy Tadalafil online at Remedy Counter without any prescription. This online pharmacy is based in the USA and provides numerous customer benefits and discounts.

When to take Tadalafil for best results?

The ED medicine should be taken 20 to 30 minutes prior to sexual activity for better results.

Does Tadalafil help with premature ejaculation?

Yes, the medicine is effective for premature ejaculation. Studies show that men on Tadalafil last longer.

Can you take Tadalafil with alcohol?

No, it can cause a sudden drop in blood pressure and can cause severe side effects.

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